Evaluation of Hepatoprotective and Lipotropic Effect of Mentha Piperita Leaf against Carbontetrachloride-induced Hepatic Damage in Rats

Herbal and plant origin crude drugs with anti-lipid peroxidative activity had become a central focus for study of hepatoprotection due to its safety, efficacy and cost effectiveness. The aim of present study is to analyse the hepatoprotective and lipotropic effect of Mentha piperita leaf in CCl4 induced free radical mediated oxidative stress rats. In the present study, an attempt has been made to evaluate the antilipid peroxidative and indirect antioxidant of crude powder of Mentha piperita against CCl4 induced free radical mediated oxidative stress. Hepatic enzyme marker such as SGPT, SGOT and MDA, glutathione, blood serum calcium, iron and lipid profile have used to evaluate hepatoprotective and lipotropic effect. The result exhibits the significant amount of hepatic cell regeneration processes though the reduction of SGPT, SGOT and MDA as well as increased in the level of glutathione towards the normal value. Similarly, lipid profile, serum calcium and iron attained towards normal of CCl4 induced oxidative stress rats after treated with the crude Mentha piperita extract. In conclusion, Mentha piperita leaf extracted may play a protective role against liver dysfunction and toxicity with the enhancement of hepatic cell regeneration processes.